PaCO2 Adjustment Calculator

This calculator helps respiratory care practitioners adjust ventilation parameters based on arterial carbon dioxide (PaCO2) levels. When a patient's PaCO2 is not at the desired level, you can use these calculations to determine new ventilator settings by adjusting either tidal volume, respiratory rate, or both.

Clinical Note: PaCO2 is inversely proportional to alveolar ventilation. To decrease PaCO2, increase ventilation (↑VT, ↑RR, or both). To increase PaCO2, decrease ventilation (↓VT, ↓RR, or both).

Current Ventilation Parameters

40
35
12

Normal range: 12-20 breaths/min

500

Typical range: 6-8 ml/kg IBW

Calculations

Current Minute Ventilation

Minute Ventilation (VE) = Tidal Volume (VT) × Respiratory Rate (RR)

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New Minute Ventilation Required

New VE = (Current PaCO2 × Current VE) / Desired PaCO2

This calculates the exact minute ventilation needed to achieve your desired PaCO2

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Option 1: Adjust Respiratory Rate Only

New RR = (Current PaCO2 × Current RR) / Desired PaCO2

Keeps tidal volume constant while adjusting rate

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Option 2: Adjust Tidal Volume Only

New VT = (Current PaCO2 × Current VT) / Desired PaCO2

Keeps respiratory rate constant while adjusting volume

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